NDLI: Maintenance and function of antigen-specific CD4 T cells within the lung during tuberculosis

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Maintenance and function of antigen-specific CD4 T cells within the lung during tuberculosis

Content Provider	Semantic Scholar
Author	Moguche, Albanus O.
Copyright Year	2014
Abstract	Maintenance and function of antigen-specific CD4 T cells within the lung during tuberculosis ALBANUS OBONSI MOGUCHE Chair of Supervisory Committee: Kevin B. Urdahl, M.D., Ph.D. Department of Immunology Tuberculosis (TB) is a chronic pulmonary disease caused by the intracellular bacterium Mycobacterium tuberculosis (Mtb). Even though CD4 T cells are critical for containing Mtb, the immune system rarely eradicates the bacteria, necessitating the maintaining of an antigenspecific CD4 T cell response throughout the course of infection. How this response is maintained is not currently well understood. Here we show that in a murine model of TB, Mtb-specific CD4 T cells are subjected to chronic antigenic stimulation. Despite this chronic antigenic stimulation, a subset of these Mtb-specific CD4 T cells expressing the inhibitory receptor PD-1 exhibits hallmarks of memory T cells and their maintenance requires intrinsic expression of ICOS, the transcription factor Bcl6, and the chemokine receptor CXCR5. Furthermore we find that a majority of KLRG1 IFN-γ producing CD4 T cells are located in the lung-associated vasculature and not in the lung parenchyma as previously thought. However, the PD-1 population that shares features with follicular helper (Tfh) and memory T cells is principally located within the lung parenchyma. This distribution can be largely explained by considering the TB granuloma as a tertiary lymphoid structure that forms within the
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://digital.lib.washington.edu/researchworks/bitstream/handle/1773/26105/Moguche_washington_0250E_13723.pdf?isAllowed=y&sequence=1
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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