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Role of the NO/sGC/PKG signaling pathway of hippocampal CA1 in morphine-induced reward memory
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shen, Fang Li, Yi-Jing Shou, Xiao-Jing Cui, Cai-Lian |
| Copyright Year | 2012 |
| Abstract | Evidence suggests that the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP dependent protein kinase (PKG) signaling pathway plays a key role in memory processing, but the actual participation of this signaling cascade in the hippocampal CA1 during morphine-induced reward memory remains unknown. In this study, we investigated the role of the NO/sGC/PKG signaling pathway in the CA1 on morphine-induced reward memory using a conditioned place preference (CPP) paradigm. We found that rats receiving an intraperitoneal (i.p.) injection of 4mg/kg morphine exhibited CPP, whereas rats treated with only 0.2mg/kg morphine failed to produce CPP. Intra-CA1 injection of the neuronal NO synthase (nNOS) inhibitor 7-NI, the sGC inhibitor ODQ or the PKG inhibitor Rp-8-Br-PET-cGMPS had no effect on the acquisition of CPP by 4mg/kg morphine. Intra-CA1 injection of 7-NI blocked the consolidation of CPP induced by 4mg/kg morphine, and this amnesic effect of 7-NI was mimicked by ODQ and Rp-8-Br-PET-cGMPS. Intra-CA1 injection of the NOS substrate L-arg or the sGC activator YC-1 with an ineffective dose of morphine (0.2mg/kg, i.p.) elicited CPP. This response induced by L-arg or YC-1 was reversed by pre-microinjection of Rp-8-Br-PET-cGMPS in the CA1. These results indicated that the activation of the NO/sGC/PKG signaling pathway in the CA1 is necessary for the consolidation of morphine-related reward memory. |
| Starting Page | 130 |
| Ending Page | 138 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.nlm.2012.07.005 |
| PubMed reference number | 22820534 |
| Journal | Medline |
| Volume Number | 98 |
| Alternate Webpage(s) | http://nri.bjmu.edu.cn/english/html/2012publish/1207.pdf |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S1074742712000950 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S1074742712000950?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.nlm.2012.07.005 |
| Journal | Neurobiology of Learning and Memory |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
