Adiponectin is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction in patients presenting with chest pain.

Content Provider	Semantic Scholar
Author	Cavuşoğlu, Erdal Ruwende, Cyril Chopra, Vineet Yanamadala, Sunitha Clark, Luther T. Pinsky, David J. Marmur, Jonathan D.
Copyright Year	2006
Abstract	AIMS To determine the prognostic value of baseline plasma adiponectin levels in patients with known or suspected coronary artery disease referred for coronary angiography. METHODS AND RESULTS Adiponectin was measured in 325 male patients with stable angina, troponin-negative unstable angina, and non-ST-segment elevation myocardial infarction (MI) undergoing coronary angiography at a Veterans Administration Medical Center. The patients were then followed prospectively for the occurrence of all-cause mortality, cardiac mortality, and MI. Follow-up data at 24 months were available for 97% of the patients. Adiponectin was the only biomarker to independently predict the individual endpoints of all-cause mortality, cardiac mortality, and MI. The 24-month survival rates for patients in the lower (< or =4.431 mg/L), middle (>4.431 and < or =8.008 mg/L), and upper (>8.008 mg/L) tertiles of plasma adiponectin values were 95.0, 90.4, and 83.5%, respectively (P = 0.0232 by log-rank test). Furthermore, when patients with chest pain were risk-stratified into those with and without a non-ST-segment elevation acute coronary syndrome (NSTEACS), adiponectin remained an independent predictor of both all-cause mortality and cardiac mortality in the NSTEACS subgroup. CONCLUSION In a cohort of male patients undergoing coronary angiography, a single baseline determination of plasma adiponectin is independently predictive of the subsequent risk of death and MI.
Starting Page	921
Ending Page	925
Page Count	5
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.marmur.com/PDFs/Adiponectin%20is%20an%20independent%20predictor%20EHJ%202006.pdf
PubMed reference number	16864609v1
Volume Number	27
Issue Number	19
Journal	European heart journal
Language	English
Access Restriction	Open
Subject Keyword	ADIPOQ gene Acute Coronary Syndrome Adiponectin Angina Pectoris Arteriopathic disease Artificial cardiac pacemaker Biological Markers Cessation of life Chest Pain Coronary Artery Disease Coronary angiography Myocardial Infarction Patients Unstable Medical Device Problem angiogram
Content Type	Text
Resource Type	Article