Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio).

Content Provider	Semantic Scholar
Author	Song, Seog Beom Xu, Yiping Zhou, Bing Sheng
Copyright Year	2006
Abstract	Hexachlorobenzene (HCB)-induced oxidative damages have been published in rats while the effects have not yet been reported in fishes. Juvenile common carps (Cyprinus carpio) were exposed to waterborne HCB from 2 to 200 microg l-1 for 5, 10 or 20 days. Liver and brain were analyzed for various parameters of oxidative stress. There were no significant changes of glutathione (GSH) content and superoxide dismutase (SOD) activity in liver after 5 or 10 days exposure, whereas obvious drops were observed at higher concentrations after 20 days exposure. Significant decreases of GSH content and SOD activity in brain were found during all the exposure days. In brain, HCB also significantly elevated the contents of reactive oxygen species (ROS), thiobarbituric acid- reactive substances (TBARS, as an indicator of lipid peroxidation products), glutathione disulfide (GSSG), and activities of nitric oxide synthase (NOS), glutathione peroxidase (GPx), and glutathione reductase (GR), and inhibited activities of acetylcholinesterase (AchE) and glutathione S-transferase (GST). The results clearly demonstrated that environmentally possible level of HCB could result in oxidative stress in fish and brain was a sensitive target organ of HCB toxicity.
Starting Page	699
Ending Page	706
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ir.ihb.ac.cn/bitstream/152342/8806/1/Effects%20of%20hexachlorobenzene%20on%20antioxidant%20status%20of%20liver%20and%20brain%20of%20common%20carp%20(Cyprinus%20carpio).pdf
PubMed reference number	16497358v1
Volume Number	65
Issue Number	4
Journal	Chemosphere
Language	English
Access Restriction	Open
Subject Keyword	Acetylcholinesterase Adverse reaction to drug Carassius auratus red var. x Cyprinus carpio Carp, fish Fishes GLUTATHIONE PEROXIDASE Glutathione Disulfide Glutathione S-Transferase Hexachlorobenzene Juvenile arthritis Lipid Peroxidation Nitric Oxide Synthase Organ Oxidative Stress Psychological inhibition Reactive Oxygen Species Scientific Publication Superoxide Dismutase Superoxides Thiobarbituric Acid Reactive Substances Transferase contents - HtmlLinkType downregulation of ferrisuperoxide dismutase activity
Content Type	Text
Resource Type	Article