A Convenient Synthesis for HBED-CC-tris ( tert-butyl ester )

Content Provider	Semantic Scholar
Author	Makarem, Ata Konrad, M. Hade J. M. Liolios, Christos Kopka, Klaus
Copyright Year	2018
Abstract	HBED-CC is a bifunctional complexing agent that, at ambient temperature, tightly chelates the trivalent radiometal 68Ga (T1/2 = 68 min). This complexing agent has attracted a lot of interest in tumor imaging applications. Depending on the chemical structure, different HBED-CC variants may be employed as radiolabeling precursor for the synthesis of desired radiopharmaceuticals. In this context, HBED-CCtris(tert-butyl ester) is the only known monovalent variant of HBED-CC which is used for the synthesis of non-symmetric HBED-CC-based radiopharmaceuticals. Commercial HBED-CC-tris(tert-butyl ester) is very expensive, with limited availability. Nevertheless, no synthetic procedure for this useful product has been reported to date. This work introduces a convenient and comparatively cost-efficient method for the preparation of HBED-CC-tris(tert-butyl ester).
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0036-1591950.pdf
Language	English
Access Restriction	Open
Subject Keyword	CC system Chelating Agents Chemical Structure Clomiphene Cost efficiency Esters Limited availability Maxima and minima NG-Nitroarginine Methyl Ester Neoplasms Radioisotopic Labeling (lab procedure) Radiopharmaceuticals Synthetic intelligence Tromethamine tert-Butyl Alcohol
Content Type	Text
Resource Type	Article