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5-fluorocytosine and amphotericin B in bronchial secretions.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Pennington, J. E. Block, Edward R. Reynolds, Herbert Y. |
| Copyright Year | 1974 |
| Abstract | The penetration into and clearance from bronchial secretions of 5-fluorocytosine and amphotericin B were studied in a dog model. After a single intravenous dose of 35 mg/kg, 5-fluorocytosine intrabronchial concentrations were greater than the minimal inhibitory concentration for 80 to 90% of Candida species. These inhibitory concentrations persisted up to 3 h. In contrast, amphotericin B in intravenous doses of 0.6 and 1.2 mg/kg penetrated the blood-bronchus barrier poorly. |
| File Format | PDF HTM / HTML |
| DOI | 10.1128/AAC.6.3.324 |
| Alternate Webpage(s) | http://aac.asm.org/content/6/3/324.full.pdf |
| PubMed reference number | 15830481 |
| Alternate Webpage(s) | https://doi.org/10.1128/AAC.6.3.324 |
| Journal | Medline |
| Volume Number | 6 |
| Issue Number | 3 |
| Journal | Antimicrobial agents and chemotherapy |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
