NDLI: Medulloblastoma growth inhibition by hedgehog pathway blockade.

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Medulloblastoma growth inhibition by hedgehog pathway blockade.

Content Provider	Semantic Scholar
Author	Berman, David M. Karhadkar, Sunil S. Hallahan, Andrew R. Pritchard, Joel I. Eberhart, Charles G. Watkins, D. Neil Chen, James K. Cooper, Michael K. Taipale, Jussi Olson, James M. Beachy, Philip A.
Copyright Year	2002
Abstract	Constitutive Hedgehog (Hh) pathway activity is associated with initiation of neoplasia, but its role in the continued growth of established tumors is unclear. Here, we investigate the therapeutic efficacy of the Hh pathway antagonist cyclopamine in preclinical models of medulloblastoma, the most common malignant brain tumor in children. Cyclopamine treatment of murine medulloblastoma cells blocked proliferation in vitro and induced changes in gene expression consistent with initiation of neuronal differentiation and loss of neuronal stem cell-like character. This compound also caused regression of murine tumor allografts in vivo and induced rapid death of cells from freshly resected human medulloblastomas, but not from other brain tumors, thus establishing a specific role for Hh pathway activity in medulloblastoma growth.
Starting Page	95
Ending Page	101
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://research.fhcrc.org/content/dam/stripe/olson/files/Medulloblastoma_Growth_inhibition_by_hedgehog_pathway_blocka.pdf
PubMed reference number	12202832v1
Volume Number	297
Issue Number	5586
Journal	Science
Language	English
Access Restriction	Open
Subject Keyword	Allograft surgical material Brain Neoplasms Cognitive function: initiation Erinaceidae Gene Expression Malignant neoplasm of brain Medulloblastoma Stem cells Transcription Initiation cyclopamine omacetaxine mepesuccinate
Content Type	Text
Resource Type	Article

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