Effects of glutathione S-transferase M1 and T1 deletions on epilepsy risk among a Tunisian population

Content Provider	Semantic Scholar
Author	Chbili, Chahra B’chir, Fatma Fredj, M. Ben Saguem, Bochra-Nourhène Saguem, Sâad
Copyright Year	2014
Abstract	Glutathione-S-transferases enzymes are involved in the detoxification of several endogenous and exogenous substances. In this present study, we evaluated the effects of two glutathione-S-transferase polymorphisms, (GSTM1 and GSTT1) on epilepsy risk susceptibility in a Tunisian population. These polymorphisms were analyzed in 229 healthy subjects and 98 patients with epilepsy, using a polymerase chain reaction (PCR). Odds ratio (ORs) was used for analyzing results. The study results demonstrated that individuals with the GSTM1 null genotype were at an increased risk of developing epilepsy [OR=3.80, 95% confidence interval (CI) (2.15-4.78)], whereas no significant effects were observed between individuals with GSTT1 null genotype and epilepsy risk [OR=1.15, 95% CI (0.62-2.12)]. These genotyping finding revealed that the absence of GSTM1 activity could be contributor factor for the development of epilepsy disease.
Starting Page	1168
Ending Page	1173
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1016/j.eplepsyres.2014.05.009
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0920121114001417
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0920121114001417?dgcid=api_sd_search-api-endpoint
PubMed reference number	24970787
Alternate Webpage(s)	https://doi.org/10.1016/j.eplepsyres.2014.05.009
Journal	Medline
Volume Number	108
Journal	Epilepsy Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article