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Predictors of initiating rapid-acting insulin analog using vial/syringe, prefilled pen, and reusable pen devices in patients with type 2 diabetes.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lee, Lauren J. Anderson, Julie Foster, Shonda A. Corrigan, Sheila M. Smith, David M. Curkendall, Suellen M. |
| Copyright Year | 2010 |
| Abstract | BACKGROUND Limited data are available on the predictors of insulin delivery device choice. This study assessed the patient- and health-care-system-related factors that predict the initiation of one rapid-acting insulin analog (RAIA) delivery system over another. METHODS A retrospective analysis using a claims database (January 1, 2007, through March 31, 2009) was conducted. Patients were required to be diagnosed with type 2 diabetes mellitus, and have >or=12 months of continuous eligibility prior to their first prescription of a RAIA on or after January 1, 2008. The three cohorts in the study were vial/syringe (n = 6820), prefilled pen (n = 5840), and reusable pen (n = 2052). Multiple factors were examined using stepwise logistic regression. RESULTS Factors that increased the likelihood of initiating RAIA using prefilled pen versus vial/syringe included endocrinologist visit [odds ratio (OR) = 3.13, 95% confidence interval (CI) = 2.56, 3.82], prior basal insulin use with pen (OR = 4.85, 95% CI = 4.21, 5.59), and use of >or=1 oral antihyperglycemic agents (OR = 1.32, 95% CI = 1.20, 1.45). Factors that decreased the likelihood included inpatient admission (OR = 0.76, 95% CI = 0.70, 0.83), nursing home visit (OR = 0.22, 95% CI = 0.18, 0.27), and obesity (OR = 0.67, 95% CI = 0.53, 0.83). There were fewer differences between prefilled and reusable pen initiators. Factors that increased the likelihood of initiating with prefilled versus reusable pen included endocrinologist visit (OR = 1.87, CI = 1.50, 2.34) and inpatient admission (OR = 1.46, 95% CI = 1.30, 1.64). CONCLUSION Significant differences in predictors were observed between prefilled pen and vial/syringe initiators. The differences were fewer between prefilled and reusable pen initiators. These differences should be taken into consideration when evaluating outcomes associated with specific insulin delivery systems. |
| Starting Page | 89 |
| Ending Page | 97 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jdst.org/May2010/Articles/VOL-4-3-SYM6-LEE.pdf |
| PubMed reference number | 20513319v1 |
| Volume Number | 4 |
| Issue Number | 3 |
| Journal | Journal of diabetes science and technology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Analog Breast Feeding Confidence Intervals Diabetes Mellitus Diabetes Mellitus, Non-Insulin-Dependent Hypoglycemic Agents Insulin Lispro Insulin, Short-Acting Odds Ratio Patients Transcription Initiation inpatient penclomedine |
| Content Type | Text |
| Resource Type | Article |
