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Elimination of 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid when normalized to urinary creatinine
| Content Provider | Semantic Scholar |
|---|---|
| Author | Beardsley, Grant D. |
| Copyright Year | 1990 |
| Abstract | approved: Redacted for Privacy fJohn Mark Chiistensen Gas chromatography mass/spectrometry quantitative analysis of 11-nor-delta-9-tetrahydrocannabino1-9-carboxylic acid (THCCOOH), the major metabolite of delta-9-tetrahydrocannabinol (THC) found in urine following marijuana use, was performed on serial specimens collected from an inpatient adolescent population of marijuana users. Creatinine normalization of THCCOOH was used to compensate for dilute or concentrated urine specimens. The urinary terminal elimination rate constant and terminal half-life were calculated for each subject using data fit to a biexponential equation. The mean urinary elimination rate constant for THCCOOH normalized to creatinine was 0.08433 days-1 (range 0.05408 0.16544) reflecting a 8.22 day terminal half-life. Data was also collected on subjects who reused marijuana. The creatinine normalized THCCOOH level was a better indicator for predicting reuse of marijuana than urinary concentrations of THCCOOH |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://ir.library.oregonstate.edu/downloads/2801pm11f?locale=en |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
