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Prevalence of Subclinical CNV and Choriocapillaris Nonperfusion in Fellow Eyes of Unilateral Exudative AMD on OCT Angiography
| Content Provider | Semantic Scholar |
|---|---|
| Author | Treister, Alison D. Nesper, Peter L. Fayed, Alaa E. Gill, Manjot Mirza, Rukhsana G. Fawzi, Amani A. |
| Copyright Year | 2018 |
| Abstract | Purpose To determine the prevalence of subclinical choroidal neovascularization (CNV) in fellow eyes of patients with unilateral exudative age-related macular degeneration (AMD) using optical coherence tomography angiography (OCTA) and to quantify choriocapillaris nonperfusion adjacent to CNV. Methods We retrospectively reviewed all patients with AMD who underwent OCTA and identified eyes with unilateral exudative AMD. We determined the presence of subclinical CNV on custom en face macular slabs of the outer retina and choriocapillaris and confirmed on cross-sectional scans. Two graders quantified the percent choriocapillaris area of nonperfusion (PCAN) in the entire choriocapillaris slab as well as in the "halo" zone (200 μm) surrounding subclinical and exudative CNV lesions. Results Of 140 AMD patients who underwent OCTA, 34 had unilateral exudative AMD, with five of the 34 fellow eyes (14.7%) having subclinical CNV. Compared with PCAN in the entire slab (10.333 ± 4.288%), we found that "halo" PCAN, surrounding CNV, was significantly higher (13.045 ± 5.809%; P < 0.001). Further, there was a trend for higher PCAN in exudative CNV eyes (15.267 ± 7.230%) compared with their fellow subclinical CNV eyes (10.823 ± 3.365%, P = 0.115). Conclusions There is a notable prevalence of subclinical CNV in fellow eyes with unilateral exudative CNV, and significantly greater choriocapillaris nonperfusion adjacent to all CNV lesions. We identified a trend for increased choriocapillaris nonperfusion in exudative AMD eyes as compared with their fellow subclinical CNV eyes, which deserves further study. Translational Relevance OCTA can be useful in clinical practice to detect subclinical CNV and study choriocapillaris dysfunction. |
| Starting Page | e106 |
| Ending Page | e16 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 30280004v1 |
| Alternate Webpage(s) | https://doi.org/10.1167/tvst.7.5.19 |
| DOI | 10.1167/tvst.7.5.19 |
| Journal | Translational vision science & technology |
| Volume Number | 7 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bronchiolitis, Exudative Choroidal Neovascularization Choroideremia Copy Number Polymorphism Eye Macular degeneration Pathologic Neovascularization Patients Physiological Sexual Disorders Retina Structure of lamina choroidocapillaris Tomography, Optical Coherence X-Ray Computed Tomography angiogram |
| Content Type | Text |
| Resource Type | Article |
