NDLI: Analogues of Acyclic Nucleosides Derived from Tris-(Hydroxymethyl)Phosphine Oxide or Bis-(Hydroxymethyl)Phosphinic Acid Coupled to DNA Nucleobases

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Analogues of Acyclic Nucleosides Derived from Tris-(Hydroxymethyl)Phosphine Oxide or Bis-(Hydroxymethyl)Phosphinic Acid Coupled to DNA Nucleobases

Content Provider	Semantic Scholar
Author	Nawrot, Barbara Michalak, Olga Clercq, Erik De Stec, Wojciech J.
Copyright Year	2004
Abstract	A series of novel acyclic nucleoside analogues containing bis-(hydroxymethyl)phosphinic acid (BHPA) or tris(hydroxymethyl)phosphine oxide (THPO) coupled with DNA nucleobases or with 5-fluorouracil were prepared and their antiviral activity was studied against cytomegalovirus (CMV), varicella-zoster virus (VZV), parainfluenza-virus type 3, reovirus-type 1, sindbis, coxsackie B4, punta toro, vesicular stomatitis and respiratory syncytial virus, herpes simplex virus-type 1 (KOS) and type 2 (G), vaccinia virus and herpes simplex virus-1 (TK-KOS ACVr). No specific antiviral effects were noted for any of test compounds against viruses evaluated, except thymine, cytosine and adenine derivatives of BHPA exerting borderline activity against respiratory syncytial virus at the 80 mg/ml concentration.
Starting Page	319
Ending Page	328
Page Count	10
File Format	PDF HTM / HTML
DOI	10.1177/095632020401500604
Alternate Webpage(s)	https://www.intmedpress.com/serveFile.cfm?sUID=bd4232ad-fed0-4f38-84d9-8f779d019800
PubMed reference number	15646645
Alternate Webpage(s)	https://doi.org/10.1177/095632020401500604
Journal	Medline
Volume Number	15
Journal	Antiviral chemistry & chemotherapy
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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