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Invited Lectures
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bacchus-Montabonel, M. C. Tergiman, Y. Suzanne Vaeck, Nathalie Baloitcha, Ezinvi Desouter, M. Lecomte |
| Copyright Year | 2004 |
| Abstract | Today it is recognized that radiation damage in bio-molecules, in particular strand breaking in the DNA, is not only the result of a single interaction of the primary ionization projectile with the molecules involved, but also due to the simultaneous and consecutive action of the primary and the secondary species, including also radicals (for instance oxygen) that are produced by destruction of the water molecules surrounding the DNA. A detailed knowledge of the ionization process is a must for a full understanding of radiation damage on a microscopic level . The research program that we developed at the Institut de Physique Nucléaire de Lyon is focused on the study of swift proton impact ionization of biomolecules in the gas phase and of mixed clusters (DNA or RNA basis and water molecules). The proton energy range (30150 kV) explored corresponds to a range where proton beam action in living matter is known to be maximum (Bragg peak range). This program is also related to our previous results [1-3] on statistical description of collision induced fragmentation of molecular clusters. Indeed, the relaxation of these highly excited molecular complex systems is also of fundamental interest. Preliminary experiments are devoted to the measurement of fragmentation cross sections of a target molecule in coincidence with the post-collision charge state of the projectile. Therefore, we are able for the first time to separate the direct ionization and the ionization via electron capture by the projectile. This work give new insights on ionization and charge exchange processes in the interaction of protons and neutral hydrogen atoms with water and biomolecules such as DNA or RNA bases. |
| Starting Page | 772 |
| Ending Page | 774 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| DOI | 10.1111/j.1468-2982.2004.00857_1.x |
| Volume Number | 24 |
| Alternate Webpage(s) | https://www.uibk.ac.at/sasp/sasp02/boa_radab.pdf |
| Alternate Webpage(s) | https://doi.org/10.1111/j.1468-2982.2004.00857_1.x |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
