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Hepatitis C virus infection is associated with the development of hepatocellular carcinoma.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Saito, Ikuo Miyamura, Tatsuo Ohbayashi, Akira Harada, Hirotada Katayama, Taiichi Kikuchi, Shoshi Watanabe, Yukio Koi, Sumiko Onji, Morikazu Ohta, Y. |
| Copyright Year | 1990 |
| Abstract | A possible causative role for the recently discovered hepatitis C virus (HCV) in the development of hepatocellular carcinoma (HCC) was investigated by assay of sera from HCC patients in Japan for antibodies to a recombinant HCV antigen and to hepatitis B virus (HBV) antigens. Among the 253 HCC patients examined, 156 (61.7%) had no serum markers of either a previous or a current HBV infection (group I), 46 (18.2%) were negative for HBV surface antigen but positive for anti-HBV surface and/or anti-HBV core antibody, indicating the occurrence of a previous, transient HBV infection (group II), and 51 (20.2%) were chronically infected HBV carriers as evidenced by positivity for HBV surface antigen (group III). The prevalence of HCV antibody in group I (68.6%) and II (58.7%) patients was significantly higher than for group III (3.9%) or in 148 additional patients with other (non-HCC) cancers (10.1%) (P less than 0.01). Thus, there appears to be a strong association between HCV infection and the development of HCC, particularly in patients for which HBV infection cannot be implicated as a causative factor. The data also suggest an additional mode of transmission for HCV other than blood transfusion, since a history of blood transfusion was shown in only about 30% of the HCV antibody-positive HCC patients in groups I and II. A high prevalence of HCV antibody was also shown among patients with HCC whose disease was originally thought to be due to very high ethanol consumption. |
| File Format | PDF HTM / HTML |
| DOI | 10.1073/pnas.87.17.6547 |
| PubMed reference number | 2168552 |
| Journal | Medline |
| Volume Number | 87 |
| Issue Number | 17 |
| Alternate Webpage(s) | http://www.pnas.org/content/87/17/6547.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1073/pnas.87.17.6547 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
