Deep Brain Stimulation of the Antero-Medial Globus Pallidus Interna for Tourette Syndrome

Content Provider	Semantic Scholar
Author	Sachdev, Perminder Singh Mohan, Adith Cannon, Elisabeth Crawford, J. D. Silberstein, Paul Cook, Raymond John Coyne, Terrence Silburn, P. A.
Copyright Year	2014
Abstract	BACKGROUND We have previously reported the results of Deep Brain Stimulation (DBS) of the antero-medial globus pallidus interna (GPi) for severe Tourette Syndrome (TS) in 11 patients. We extend this case series to 17 patients and a longer follow-up to a maximum of 46 months. METHODS 17 patients (14 male; mean age 29.1 years, range 17-51 years) with severe and medically intractable TS were implanted with Medtronic quadripolar electrodes bilaterally in the antero-medial GPi. The primary outcome measure was the Yale Global Tic Severity Scale (YGTSS). Secondary outcome measures included the Yale-Brown Obsessive Compulsive Scale, Hamilton Depression Rating Scale, Gilles de la Tourette Quality of Life Scale and Global Assessment of Functioning. Follow up was at one month, three months and finally at a mean 24.1 months (range 8-46 months) following surgery. RESULTS Overall, there was a 48.3% reduction in motor tics and a 41.3% reduction in phonic tics at one month, and this improvement was maintained at final follow-up. 12 out of 17 (70.6%) patients had a>50% reduction in YGTSS score at final follow up. Only 8 patients required ongoing pharmacotherapy for tics post-surgery. Patients improved significantly on all secondary measures. Adverse consequences included lead breakage in 4 patients, infection (1), transient anxiety (2), dizziness (1), poor balance (1) and worsening of stuttering (1). CONCLUSIONS This case series provides further support that antero-medial GPi DBS is an effective and well tolerated treatment for a subgroup of severe TS, with benefits sustained up to 4 years.
File Format	PDF HTM / HTML
DOI	10.1371/journal.pone.0104926
PubMed reference number	25136825
Journal	Medline
Volume Number	9
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/a1/17/pone.0104926.PMC4138156.pdf
Alternate Webpage(s)	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0104926&type=printable
Alternate Webpage(s)	http://www.brizbrain.com.au/wp-content/uploads/PLOS-One-Deep-Brain-Stimulation-of-the-Antero-Medial-Globus-Aug-2014.pdf
Alternate Webpage(s)	https://doi.org/10.1371/journal.pone.0104926
Journal	PloS one
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article