NDLI: Hematologic effects of recombinant human granulocyte colony-stimulating factor in patients with malignancy.

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Hematologic effects of recombinant human granulocyte colony-stimulating factor in patients with malignancy.

Content Provider	Semantic Scholar
Author	Lindemann, Albrecht Herrmann, François Oster, Wolfgang Haffner, Gordon Douglas Meyenburg, W. Souza, Larry Mertelsmann, Roland Prof Dr
Copyright Year	1989
Abstract	The effect of recombinant human granulocyte colony-stimulating factor (G-CSF) on hematologic parameters was evaluated in a phase I clinical study in 18 patients with advanced malignancy. G-CSF was administered once daily as a 30-minute infusion for 14 days; three patients each were treated at increasing dose levels of 1, 3, 10, 30, and 60 micrograms kg-1 day-1. A transient decrease in neutrophil and monocyte counts was observed immediately after the G-CSF infusion, followed by a dose-dependent increase of up to 15-fold. G-CSF-induced neutrophils exhibited an increased O2- radical production, and serum levels of enzymes related to granulocyte turnover, including lysozyme and elastase, were markedly elevated during therapy. A dose-dependent depression of platelet counts occurred in the second third of the treatment course, followed by a spontaneous recovery despite continuing therapy. G-CSF was well-tolerated; minor to moderate bone pain was the most common side effect. The primary course of the malignant diseases studied was not significantly altered. G-CSF appears to be an appropriate means to selectively increase the number of functionally competent polymorphonuclear phagocytes.
File Format	PDF HTM / HTML
DOI	10.1182/blood.V74.8.2644.2644
PubMed reference number	2479425
Journal	Medline
Volume Number	74
Issue Number	8
Alternate Webpage(s)	http://www.bloodjournal.org/content/bloodjournal/74/8/2644.full.pdf?sso-checked=true
Alternate Webpage(s)	https://doi.org/10.1182/blood.V74.8.2644.2644
Journal	Blood
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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