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Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhang, Qia Joshi, Sunil K. Lovett, David H. Zhang, Bryon Bodine, Sue C. Kim, Hubert T. Liu, Xuhui |
| Copyright Year | 2014 |
| Abstract | BACKGROUND extracellular matrix (ECM) components are instrumental in maintaining homeostasis and muscle fiber functional integrity. Skeletal muscle hypertrophy is associated with ECM remodeling. Specifically, recent studies have reported the involvement of matrix metalloproteinases (MMPs) in muscle ECM remodeling. However, the functional role of MMPs in muscle hypertrophy remains largely unknown. METHODS in this study, we examined the role of MMP-2 in skeletal muscle hypertrophy using a previously validated method where the plantaris muscle of mice were subjected to mechanical overload due to the surgical removal of synergist muscles (gastrocnemius and soleus). RESULTS following two weeks of overload, we observed a significant increase in MMP-2 activity and up-regulation of ECM components and remodeling enzymes in the plantaris muscles of wild-type mice. However, MMP-2 knockout mice developed significantly less hypertrophy and ECM remodeling in response to overload compared to their wild-type littermates. Investigation of protein synthesis rate and Akt/mTOR signaling revealed no difference between wild-type and MMP-2 knockout mice, suggesting that a difference in hypertrophy was independent of protein synthesis. CONCLUSION taken together, our results suggest that MMP-2 is a key mediator of ECM remodeling in the setting of skeletal muscle hypertrophy. |
| Starting Page | 199 |
| Ending Page | 202 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.mltj.org/common/php/portiere.php?ID=a4c08ce9b50d27d94e8e271b297ed8e0 |
| PubMed reference number | 25767782v1 |
| Volume Number | 4 |
| Issue Number | 4 |
| Journal | Muscles, ligaments and tendons journal |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Extracellular Matrix Gastrocnemius muscle structure Matrix Metalloproteinase 2 Matrix Metalloproteinases Mediator brand of benfluorex hydrochloride Metalloproteases Muscle Fibers Plantaris muscle Protein Biosynthesis Proto-Oncogene Proteins c-akt Skeletal muscle hypertrophy |
| Content Type | Text |
| Resource Type | Article |
