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Ultrasonography guided diffuse optical tomography for noninvasive monitoring of breast cancer during neoadjuvant chemotherapy
| Content Provider | Semantic Scholar |
|---|---|
| Author | Dong, Yan Qiang, Jinwei Chang, Cai Zhou, Shichong |
| Copyright Year | 2016 |
| Abstract | Less costly and noninvasive imaging technique is valuable for the diagnosis of breast cancer and monitoring the treatment. This study aimed to evaluate the application of ultrasonography guided diffuse optical tomography (US-DOT) in monitoring tumor response to neoadjuvant chemotherapy (NAC) in breast cancer patients. We prospectively evaluated 90 patients with breast cancer. All patients underwent surgery after NAC. Ninety patients were scanned with US-DOT prior to, during, and at the completion of NAC. Total hemoglobin concentration (THC) and tumor diameter were measured by US-DOT. Tumor response was assessed using the Miller-Payer system. All 90 patients completed the whole NAC cycles, 20 (20%) patients showed complete disappearance of all cancerous tissue (Grade 5). Only 3 (3.44%) patients had no pathological response (Grade 1). The other 67 (76.56%) patients showed varying degrees of necrosis of cancerous tissue (Grade 2-4). The tumor diameter and THC value decreased during NAC. Tumor diameter correlated significantly with THC value of breast cancers (R=0.6). After four or six cycles of NAC, the relative variation rates (RVRs) of THC values were significantly different among the grades (P < 0.05), but THC values had no difference in three chemotherapy regimens. In conclusion, US-DOT is a powerful technique to monitor tumor response during NAC. |
| Starting Page | 1648 |
| Ending Page | 1656 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Volume Number | 9 |
| Alternate Webpage(s) | http://www.ijcem.com/files/ijcem0018907.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
