NDLI: 473 32 Interference Peptides : a Novel Therapeutic Approach Targeting Synaptic Plasticity in Drug Addiction

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473 32 Interference Peptides : a Novel Therapeutic Approach Targeting Synaptic Plasticity in Drug Addiction

Content Provider	Semantic Scholar
Author	Brebner, Karen Phillips, Anthony G. Wang, Yu Tian Wong, Tak Pan
Copyright Year	2006
Abstract	Synaptic plasticity at excitatory synapses has been proposed as the cellular substrate of information processing and memory formation in the brain under both physiological and pathological conditions, including addiction. There is a growing body of evidence that implicates long-term depression (LTD), particularly in the nucleus accumbens (NAc), as a potential mediator of drug-induced neural plasticity. In animals, behavioral sensitization is used to model enduring changes in neuronal activity and behavior that result from repeated exposure to drugs of abuse. Given the links between behavioral sensitization and enduring drug-induced neuroplasticity, it is possible that compounds that can disrupt LTD may form the basis for a rational drug development strategy for repairing abnormal synaptic functions that are related to exposure to addictive substances. The data reviewed here provide evidence that facilitated AMPAR endocytosis and LTD in the NAc is critically involved in behavioral sensitization associated with drug addiction, indicating that both the expression and possibly the induction phases of LTD may represent promising targets for developing novel therapeutics for the clinical management of drug addicts.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://biomedphys.sgu.ru/Files/LIB/Springer/%20Molecular%20Mechanisms%20of%20Synaptogenesis/42.pdf
Alternate Webpage(s)	https://pdfs.semanticscholar.org/a8e9/28e10a0ed861d28434cf3b20a04e37408fb8.pdf
Language	English
Access Restriction	Open
Subject Keyword	Addictive Behavior Cell Nucleus Depressive disorder Drug Dependence Drug abuse Information processing Interference (communication) Long-Term Synaptic Depression Mediator brand of benfluorex hydrochloride Neuronal Plasticity Nucleus Accumbens Sensitization (observable entity) Synapses Synaptic Package Manager Therapeutic procedure drug development
Content Type	Text
Resource Type	Article

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