NDLI: Not so EEZE: the 'EDHF' antagonist 14, 15 epoxyeicosa-5(Z)-enoic acid has vasodilator properties in mesenteric arteries.

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Not so EEZE: the 'EDHF' antagonist 14, 15 epoxyeicosa-5(Z)-enoic acid has vasodilator properties in mesenteric arteries.

Content Provider	Semantic Scholar
Author	Harrington, Louise S. Falck, John R. Mitchell, Jane A.
Copyright Year	2004
Abstract	P-450 metabolites, including the epoxyeicosatrienoic acids, are likely candidates for endothelial derived hyperpolarising factor (EDHF). In the present study, we confirm that the stable analogue 11-nonyloxyundec-8(Z)-enoic acid is a vasodilator of murine vessels. However, we also show that the 'epoxyeicosatrienoic acid receptor' antagonist 14,15 EEZE similarly dilates murine vessels contracted with U46619, prostaglandin F2alpha or methoxamine, but not with endothelin-1 or potassium. We suggest that 14,15 EEZE is a partial agonist for the epoxyeicosatrienoic acids/EDHF receptor. These results illustrate an important pharmacological property of this antagonists, which is being increasingly used to study the nature of EDHF.
Starting Page	e13
Ending Page	e13
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://uhra.herts.ac.uk/bitstream/handle/2299/12458/906656.pdf?sequence=2
Alternate Webpage(s)	https://uhra.herts.ac.uk/bitstream/handle/2299/12458/906656.pdf?isAllowed=y&sequence=2
PubMed reference number	15588737v1
Volume Number	506
Issue Number	2
Journal	European journal of pharmacology
Language	English
Access Restriction	Open
Subject Keyword	Amino Acids, Branched-Chain Analog Blood Vessel Dinoprost Endothelin-1 Epoxyeicosatrienoic Acid Fatty Acids, Omega-6 Mesenteric Arteries Mesentery Methoxamine Pharmacology Potassium Prostaglandins Thioctic Acid U-44619 Vasodilator Agents
Content Type	Text
Resource Type	Article

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