NDLI: Cellules souches mésenchymateuses et immunomodulation : intérêt en thérapie cellulaire et risques potentiels

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Cellules souches mésenchymateuses et immunomodulation : intérêt en thérapie cellulaire et risques potentiels

Content Provider	Semantic Scholar
Author	Dosquet, Christine Moreau, Marie
Copyright Year	2008
Abstract	Les cellules souches mesenchymateuses, en anglais mesenchymal stem cells ou multipotent mesenchymal stromal cells, sont des cellules souches multipotentes qui peuvent etre isolees facilement chez l’homme a partir notamment de la moelle osseuse. Des donnees experimentales recentes, provenant essentiellement de travaux effectues in vitro, suggerent que les MSCs sont des cellules qui echappent a la reconnaissance immune d’une part, et qui ont des proprietes immunomodulatrices, principalement immunosuppressives, d’autre part. Ces donnees ont des retombees potentiellement tres importantes en therapie cellulaire pour le traitement de maladies du greffon contre l’hote ou de maladies auto-immunes resistantes aux traitements classiques. Cependant, certaines donnees font supposer qu’il existe un risque de transformation tumorale des cellules souches mesenchymateuses et de potentialisation de la croissance tumorale. Cette mini-revue a pour but de faire un etat des lieux synthetique des connaissances et des essais cliniques de therapie cellulaire dans ce domaine.
Starting Page	189
Ending Page	193
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1684/hma.2008.0258
Volume Number	14
Alternate Webpage(s)	http://www.jle.com/download/hma-278229-cellules_souches_mesenchymateuses_et_immunomodulation_interet_en_therapie_cellulaire_et_risques_potentiels--XCYZPn8AAQEAAFXwekQAAAAB-r.pdf
Alternate Webpage(s)	https://doi.org/10.1684/hma.2008.0258
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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