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Impact of human immunodeficiency virus type 1 (hiv-1) subtype on women receiving single-dose nevirapine prophylaxis to prevent hiv-1 vertical transmission (hiv network for prevention trials 012 study).
| Content Provider | Semantic Scholar |
|---|---|
| Author | Eshleman, Susan H. Becker-Pergola, Graziella Deseyve, Martina Guay, Laura A. Mracna, Martin R. Fleming, Thomas Cunningham, Shawn P. Musoke, Philippa Mmiro, Francis A. Jackson, Jay Brooks |
| Copyright Year | 2001 |
| Abstract | In Uganda, the HIV Network for Prevention Trials (HIVNET) 012 study recently demonstrated that single-dose nevirapine (Nvp) prophylaxis is effective for preventing mother-to-child transmission (MTCT) of human immunodeficiency virus type 1 (HIV-1). This exploratory study examines the relationship between HIV-1 subtype, MTCT, and the development of Nvp resistance (Nvp(R)) in women enrolled in HIVNET 012. For 102 women (32 whose infants were HIV-1 infected by age 6-8 weeks and 70 whose infants were uninfected), HIV-1 subtypes included 50 (49%) subtype A, 35 (34%) subtype D, 4 (4%) subtype C, 12 (12%) recombinant subtype, and 1 unclassified. There was no apparent difference in the rate of MTCT among women with subtype A versus D (adjusted odds ratio [OR], 1.24; 95% confidence interval [CI], 0.45-3.43). Nvp(R) mutations were detected more frequently at 6-8 weeks postpartum in women with subtype D than in women with subtype A (adjusted OR, 4.94; 95% CI, 1.21-20.22). Additional studies are needed to further define the relationship between HIV-1 subtype and Nvp(R) among women receiving Nvp prophylaxis. |
| Starting Page | 1 |
| Ending Page | 4 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jid/184/7/10.1086/323153/2/184-7-914.pdf?Expires=1492399855&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=Btz9p62xP8zctUD50MiKrt3h1M-bQ2pCYOZUa8JQENKSaCzOP9FqC8vjK7fPrZNh69rM74LB4T5-XdUZ4GURbaOYkPKJ7D5IP7VkYATfq7vFIDi1jdruFf3GT~OXDX6yQpEA8~yF-~U9lwf~dZ9WnBLQOvLktmP3UzCZhWHbxc5j1PA13WqIfb4BWA69NHrIvSxwZ4lD0TdJjatVy8p8sDG8npIvcdtxKVbLNG1QtCeepFsYXuan6p3A8oojR4q4HiCl1FRGmUCwwR-pyq9Cki~qRyxzjHONKAP0ByArvHVR29WMqBz~W2P1bz-oiJkWVisGsCH7DXloy0PjMcvliw__ |
| PubMed reference number | 11509999v1 |
| Volume Number | 184 |
| Issue Number | 7 |
| Journal | The Journal of infectious diseases |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Confidence Intervals Forty Nine HIV Infections HIV-1 Immunologic Deficiency Syndromes Mutation Nevirapine Recombinants Subtype (attribute) Thyroid Hormone Resistance Syndrome Vertical Disease Transmission pan-PIM Kinase Inhibitor NVP-LGB-321 |
| Content Type | Text |
| Resource Type | Article |
