NDLI: Depressant effect of marihuana smoke on antibactericidal activity of pulmonary alveolar macrophages.

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Depressant effect of marihuana smoke on antibactericidal activity of pulmonary alveolar macrophages.

Content Provider	Semantic Scholar
Author	Huber, Gary L. Simmons, Guy McCarthy, Charles R. Cutting, M. B. Laguarda, R. Pereira, W. F.
Copyright Year	1975
Abstract	Other than the potentially therapeutic bronchodilatory influences of marihuana, very little is known of its biologic effects on the lung. To evaluate this problem, alveolar macrophages were harvested from rats by bronchopulmonary lavage and incubated in vitro with Staphylococcus albus and marihuana smoke of standardized 2.2-percent tetrahydrocannabinol content in graded amounts. After three hours, control alveolar macrophages inactivated 78.0 +/- 5.0 percent of the staphylococcal challenge. There was a dose-dependent depression of alveolar macrophage bactericidal activity, with 66.7 +/- 7.1 percent, 23.7 +/- 7.0 percent, 20.5 +/- 7.0 percent, and 11.4 +/- 7.6 percent of the bacteria killed following exposures to 2 ml, 4 ml, 6 ml, or 8 ml of marihuana smoke, respectively. Differential filtration of marihuana smoke revealed that the alveolar macrophage cytotoxin was present in the gas phase of the smoke and was water-soluble. Studies on purified tetrahydrocannabinol and on tetrahydrocannoabinol-extracted marihuana revealed that the impairment in alveolar macrophage function was not related to the psychomimetic or bronchodilatory components of marihuana.
Starting Page	27
Ending Page	33
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://journal.publications.chestnet.org/pdfaccess.ashx?url=/data/journals/chest/20974/769.pdf
PubMed reference number	1192853v1
Volume Number	68
Issue Number	6
Journal	Chest
Language	English
Access Restriction	Open
Subject Keyword	Biological Factors Bronchoalveolar Lavage Cannabis substance Cytotoxin Depressive disorder Extraction Irrigation Macrophages, Alveolar Smoke Inhalation Injury Structure of parenchyma of lung Tetrahydrocannabinol
Content Type	Text
Resource Type	Article

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