NDLI: Cerebral circulation in chronic arterial hypertension.

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Cerebral circulation in chronic arterial hypertension.

Content Provider	Semantic Scholar
Author	Baumbach, Gary L. Heistad, Donald D.
Copyright Year	1988
Abstract	Several new concepts have emerged recently regarding the effects of chronic hypertension on cerebral blood vessels. First, hypertrophy of large cerebral arteries in chronic hypertension attenuates increases in pressure of downstream vessels and protects the cerebral microvasculature. Second, in contrast to large cerebral arteries, which become less distensible during chronic hypertension, distensibility of cerebral arterioles increases during chronic hypertension despite hypertrophy of the arteriolar wall. Third, dilatation of cerebral blood vessels with disruption of the blood-brain barrier, and not vasospasm, appears to be the critical factor in the pathogenesis of hypertensive encephalopathy. This concept is supported by the finding that cerebral edema in stroke-prone spontaneously hypertensive rats is preceded by vasodilatation and disruption of the barrier. Fourth, alterations of endothelium-mediated dilatation may impair vasodilator responses in chronic hypertension and predispose to ischemia. Finally, chronic hypertension impairs dilatation of collateral blood vessels in the cerebral circulation. The implication of this finding is that increased susceptibility to cerebral infarction in chronic hypertension may be related in part to compromised responses of the collateral circulation.
Starting Page	89
Ending Page	95
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://hyper.ahajournals.org/content/hypertensionaha/12/2/89.full.pdf
PubMed reference number	3044994v1
Volume Number	12
Issue Number	2
Journal	Hypertension
Language	English
Access Restriction	Open
Subject Keyword	Arteries Blood - brain barrier anatomy Blood Vessel Brain Diseases Cerebral Edema Cerebral Infarction Cerebrovascular Circulation Cerebrovascular accident Collateral Circulation Dilate procedure Hypertensive Encephalopathy Hypertensive disease Hypertrophy Intracranial Hemorrhage, Hypertensive Ischemia Structure of arteriole Structure of cerebral artery Vasodilation Vasodilator Agents Vasospasm, Intracranial
Content Type	Text
Resource Type	Article

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