NDLI: Identification and characterization of major constituents in Juglans mandshurica using ultra performance liquid chromatography coupled with time-of-flight mass spectrometry (UPLC-ESI-Q-TOF/MS).

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Identification and characterization of major constituents in Juglans mandshurica using ultra performance liquid chromatography coupled with time-of-flight mass spectrometry (UPLC-ESI-Q-TOF/MS).

Content Provider	Semantic Scholar
Author	Huo, Jin-Hai Du, Xiao-Wei Sun, Guo-Dong Dong, Wen-Ting Wang, Wei-Ming
Copyright Year	2018
Abstract	The present study was designed to identify and characterize the major constituents in Juglans mandshurica Maxim. A simple, efficient and sensitive ultra performance liquid chromatography coupled with time-of-flight mass spectrometry (UPLC-ESI-Q-TOF/MS) method was established and validated under positive and negative ion modes. The separation was performed on a Waters ACQUITY UPLC BEH C18 column (2.1 mm × 100 mm, 1.7 μm) by gradient elution with a mobile phase (Phase A: 0.1% aqueous formic acid solution, Phase B: 0.1% formic acid acetonitrile solution). A total of 165 compounds were rapidly selected by Targeted and Non-Targeted Peak Finding approaches, and then tentatively identifled by comparing with reference substances or inferred through mass spectrometry fragment ion analysis and literature data. These compounds included 68 naphthalenequinones, 20 diarylheptanoids, 29 flavonoids, 20 triterpenes, and 28 phenolic acids. In conclusion, the present study provided an effective approach to identifying components in complex matrices of herbal medicines such as Juglans mandshurica Maxim.
Starting Page	525
Ending Page	545
Page Count	21
File Format	PDF HTM / HTML
DOI	10.1016/S1875-5364(18)30089-X
Alternate Webpage(s)	http://www.cjnmcpu.com/fileZGTRYW/journal/article/cjnm/2018/7/PDF/cjnm-16-7-525.pdf
PubMed reference number	30080652
Alternate Webpage(s)	https://doi.org/10.1016/S1875-5364%2818%2930089-X
Journal	Medline
Volume Number	16
Issue Number	7
Journal	Chinese journal of natural medicines
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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