NDLI: H-Wave induces arteriolar vasodilation in rat striated muscle via nitric oxide-mediated mechanisms.

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H-Wave induces arteriolar vasodilation in rat striated muscle via nitric oxide-mediated mechanisms.

Content Provider	Semantic Scholar
Author	Smith, Thomas L. Blum, Kenneth Callahan, Michael F. Dinubile, Nicholas A. Chen, Thomas J. H. Waite, Roger L.
Copyright Year	2009
Abstract	H-Wave electrical device stimulation (HWDS) is used clinically to expedite recovery from soft tissue injuries. We hypothesized that HWDS induces arteriolar dilation, a mechanism involved in the healing process. Acute effects of HWDS on striated muscle arteriolar diameters were studied. Arteriolar diameters were measured in the cremaster muscle of 57 male anesthetized rats using intravital microscopy before and after HWDS or sham stimulation (SS) at 1 or 2 Hz for periods of 30-60 min. In a separate cohort, the role of nitric oxide (NO) in the response to HWDS was assessed by blocking NO synthase using topical L-NAME at 10(-5) M. Maximal arteriolar responses to stimulation were compared to prestimulation diameters. HWDS both at 1 and 2 Hz resulted in significant arteriolar vasodilation (p < 0.05). The arterioles in SS animals demonstrated no changes in diameter. Similarly, microvascular diameters did not change with HWDS following blockade of NO production. Because of Poiseuille's Law, the significant arteriolar dilation induced by HWDS would translate into increases in blood flow of 26-62%. In addition, lack of arteriolar dilation following HWDS with blockade of NO production suggests that NO plays a role in the microvascular response to HWDS. These studies suggest that arteriolar vasodilation accompanying HWDS may result in increased perfusion, contributing to the observed therapeutic effects of HWDS.
Starting Page	391
Ending Page	425
Page Count	35
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://wayneandgary.com/edits/widgets/H-Wave%20Abstracts%20PubMed%202010.pdf
PubMed reference number	19204915v1
Alternate Webpage(s)	https://doi.org/10.1002/jor.20851
DOI	10.1002/jor.20851
Journal	Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Volume Number	27
Issue Number	9
Language	English
Access Restriction	Open
Subject Keyword	Arteriolar Vasodilation [PE] Contribution Diameter (qualifier value) Hertz (Hz) Muscle, Striated NG-Nitroarginine Methyl Ester Nitric Oxide Synthase Pathological Dilatation Soft Tissue Injuries Structure of arteriole Structure of cremaster muscle
Content Type	Text
Resource Type	Article

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