Loading...
Please wait, while we are loading the content...
Similar Documents
Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Al-Azzawie, Hasan F. Alhamdani, M. S. |
| Copyright Year | 2006 |
| Abstract | Patients with diabetes mellitus are likely to develop certain complication such as retinopathy, nephropathy and neuropathy as a result of oxidative stress and overwhelming free radicals. Treatment of diabetic patients with antioxidant may be of advantage in attenuating these complications. Oleuropein, the active constituent of olive leaf (Olea europaea), has been endowed with many beneficial and health promoting properties mostly linked to its antioxidant activity. This study aimed to evaluate the significance of supplementation of oleuropein in reducing oxidative stress and hyperglycemia in alloxan-induced diabetic rabbits. After induction of diabetes, a significant rise in plasma and erythrocyte malondialdehyde (MDA) and blood glucose as well as alteration in enzymatic and non-enzymatic antioxidants was observed in all diabetic animals. During 16 weeks of treatment of diabetic rabbits with 20 mg/kg body weight of oleuropein the levels of MDA along with blood glucose and most of the enzymatic and non-enzymatic antioxidants were significantly restored to establish values that were not different from normal control rabbits. Untreated diabetic rabbits on the other hand demonstrated persistent alterations in the oxidative stress marker MDA, blood glucose and the antioxidant parameters. These results demonstrate that oleuropein may be of advantage in inhibiting hyperglycemia and oxidative stress induced by diabetes and suggest that administration of oleuropein may be helpful in the prevention of diabetic complications associated with oxidative stress. |
| Starting Page | 95 |
| Ending Page | 101 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.health-ingredients.com/Content/File_Img/health-ingredients.com/qq/Hypoglycemic%20and%20antoxidant%20effect%20of%20oleuropein%20in%20alloxan-diabetic%20rabbits.pdf |
| PubMed reference number | 16236331v1 |
| Volume Number | 78 |
| Issue Number | 12 |
| Journal | Life sciences |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 3,4-Methylenedioxyamphetamine Alloxan Antioxidants Complications of Diabetes Mellitus Erythrocytes Free Radicals Glucose Hematological Disease Hyperglycemia Hypoglycemic Agents Inhibition Kidney Diseases Malondialdehyde Olea (plant) Olea europaea pollen Ab.IgE:ACnc:Pt:Ser:Qn Oxidative Stress Patients Promotion (action) Rabbits Retinal Diseases antioxidant activity mg/kg nervous system disorder oleuropein |
| Content Type | Text |
| Resource Type | Article |
