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Evaluation Of Transforming Growth Factor (Tgf- ) And Epidermal Growth Factor Receptor (Egfr) Expression In Oral Squamous Cell Carcinoma
| Content Provider | Semantic Scholar |
|---|---|
| Author | Abbas, Effat Ahmed Abdel-Aal, Wafaa E. Samy, A. Anthoni |
| Copyright Year | 2002 |
| Abstract | Objective: The present study aimed to investigate the pattern of expression of transforming growth factor & (TGF-&) and epidermal growth factor receptor (EGFR) in oral squamous cell carcinoma (OSCC) and to correlate their expression with tumor grading. Methods: ' ( ' ) *! +#,, )) ) Results:For both markers, positive staining reaction was characterized by cytoplasmic or cytoplasmic and membranous staining. EGFR was expre ' ./& ' 0 1! 2 ) ) ' particularly strong at the margin of invading cords and nests of tumour cells and poorly differentiated malignant cells. The expression of both markers was significantly correlated with histological grading; while the staining intensity showed no correlation with tumor grading. Conclusion: This study showed that OSCC express both EGFR and TGF-& and their expression indicated that these markers may have a potential diagnostic value in histologic examination. In addition their increased expression in high tumour grades suggest that they may be used as indicators of tumor aggressiveness. |
| Starting Page | 168 |
| Ending Page | 176 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.12816/ejhm.2002.18849 |
| Alternate Webpage(s) | https://ejhm.journals.ekb.eg/article_18849_c0c36706a78ca8c1e00017d605974013.pdf |
| Alternate Webpage(s) | https://doi.org/10.12816/ejhm.2002.18849 |
| Volume Number | 7 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
