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Highly regio-, diastereo- and enantioselective one-pot gold/chiral Brønsted acid-catalysed cascade synthesis of bioactive diversely substituted tetrahydroquinolines.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Liu, Xin-Yuan Xiao, Yaping Siu, Fung-Ming Chen, Yong Wang, Lin Che, Chi-Ming |
| Copyright Year | 2012 |
| Abstract | One-pot sequential asymmetric reactions of aminobenzaldehydes or aminophenones with alkynes catalysed by a gold(I)/Brønsted acid cooperative system are reported. This process provides a highly efficient method for the synthesis of optically active tetrahydroquinolines, with one or two chiral centres at different positions as well as highly divergent functional groups, in good to excellent yields and with high regio-, diastereo- and enantioselectivities. A preliminary study on the effect of stereochemistry on biological activity suggests a potential application of these optically active tetrahydroquinolines in drug discovery processes. |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c2ob25753j |
| PubMed reference number | 22785458 |
| Journal | Medline |
| Volume Number | 10 |
| Issue Number | 35 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/ob/c2/c2ob25753j/c2ob25753j.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/c2ob25753j |
| Journal | Organic & biomolecular chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
