NDLI: Differentiation antigens identify subpopulations of rabbit T and B lymphocytes. Definition by flow cytometry

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Differentiation antigens identify subpopulations of rabbit T and B lymphocytes. Definition by flow cytometry

Content Provider	Semantic Scholar
Author	Jackson, Sadhana Chused, Thomas M. Wilkinson, Jenny M. Leiserson, William M. Kindt, Thomas J.
Copyright Year	1983
Abstract	A panel of six monoclonal antibodies produced against cell surface glycoproteins of a rabbit T lymphocyte line was used with flow cytometry to define rabbit lymphocyte subpopulations. Four thymocyte populations were characterized by size and expression of cell surface antigens and appear to represent stages in thymocyte differentiation. Rabbit spleen contained five subpopulations: two of T lineage, two of B, and a null cell subset. Bimodal distribution of staining of thymocytes and peripheral T cells was observed using an antibody (9AE10) directed against a Thy-1 analogue in the rabbit, suggesting two separate T cell lineages. One of the monoclonal reagents, L11/135, reacted strongly with peripheral rabbit T cells as shown by two-color immunofluorescence. In functional studies, only the L11/135-bearing cells responded to the T cell mitogens concanavalin A and phytohemagglutinin and to allogeneic splenocytes. The thymocyte subpopulations and the peripheral T and B cell subsets differ from those described in mouse and man.
Starting Page	34
Ending Page	46
Page Count	13
File Format	PDF HTM / HTML
PubMed reference number	6600269v1
Volume Number	157
Journal	The Journal of experimental medicine
Alternate Webpage(s)	https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e0/30/je157134.PMC2186890.pdf
Language	English
Access Restriction	Open
Subject Keyword	Analog Concanavalin A Contain (action) Flow Cytometry GVAX prostate cancer vaccine HIV Antigens Helper-Inducer T-Lymphocyte Leukemia, B-Cell Lymphocyte Subset Membrane Glycoproteins Mitogens Null cell Peripheral T-Cell Lymphoma Phytohemagglutinins Reagents Spleen Tissue Splenocyte Staining method Subgroup T-Cell Differentiation in the Thymus polysaccharide-K thymocyte
Content Type	Text
Resource Type	Article

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