NDLI: The potential role of a corticotropin-releasing factor receptor-1 antagonist in psychiatric disorders.

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The potential role of a corticotropin-releasing factor receptor-1 antagonist in psychiatric disorders.

Content Provider	Semantic Scholar
Author	Stahl, Stephen M. Wise, Dana D.
Copyright Year	2008
Abstract	CNS Spectr 13:6 June 2008 467 NEW TREND IN PSYCHOPHARMACOLOGY The hypothalamic-pituitary-adrenal axis is a key mediator of the stress response in humans. The corticotropin-releasing factor (CRF) type 1 receptor (CRFR-1) in the pituitary gland is a gatekeeper for that response, and the CRFR-1 receptor is also present in many other moodand cognition-related neural structures. Behaviorally, a number of relationships between stress and psychiatric disorders can be observed: chronic or repeated stress is associated with onset of depression; stressors can cause a recovering alcoholic to relapse; overactive stress responses mark many anxiety disorders; and insomnia can arise from an overactive stress response. Thus, a CRFR-1 antagonist could be useful for treating or preventing the consequences of CRF-mediated stress in depression, anxiety, insomnia, and substance abuse.
Starting Page	468
Ending Page	472
Page Count	5
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.psy-world.com/0608CNS_Stahl.pdf
PubMed reference number	18567971v1
Volume Number	13
Issue Number	6
Journal	CNS spectrums
Language	English
Access Restriction	Open
Subject Keyword	AVPR1b protein, human Adrenal Glands Alcoholic Intoxication, Chronic Alcoholics Amygdaloid structure Anxiety Disorders Arginine Argipressin Axis vertebra Cognition Compulsive Personality Disorder Corticotropin-Releasing Hormone Depressive disorder Ephedra sinica Epinephrine Ethanol Generalized Anxiety Disorder Major Depressive Disorder Mediator brand of benfluorex hydrochloride Mental disorders Mj Ab:ACnc:Pt:Ser:Qn:IA Obsessive-Compulsive Disorder Orthopsychiatry Post-Traumatic Stress Disorder Psychiatry Specialty Sleeplessness Sm antibody Small Somatotropin-Releasing Hormone Stress Disorders, Traumatic Substance abuse problem Subtype (attribute) Temporomandibular Joint Disorders aloe vera leaf extract biological adaptation to stress desmopressin hypothalamic-pituitary-adrenal axis negative regulation of death-inducing signaling complex assembly receptor
Content Type	Text
Resource Type	Article

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