The pathological cross talk between apolipoprotein E and amyloid-beta peptide in Alzheimer's disease: emerging gene-based therapeutic approaches.

Content Provider	Semantic Scholar
Author	Iurescia, Sandra Fioretti, Daniela Piergili Mangialasche, Francesca Rinaldi, Monica
Copyright Year	2010
Abstract	Apolipoprotein E (ApoE) plays a key role in lipid transport in the plasma and in the central nervous system through its interaction with members of the low-density lipoprotein receptor family. The three common isoforms of ApoE (ApoE2, ApoE3, and ApoE4) differ in their ability to perform neuronal maintenance and repair functions and differentially affect the risk of developing neurodegenerative disorders. The ApoE4 isoform is a strong genetic risk factor for Alzheimer's disease. Up-to-date knowledge about the structural and biophysical features of ApoE4 shed light on the molecular basis underlying the isoform-specific pathogenic role of ApoE4 and its contribution to AD pathology through several different mechanisms. ApoE4 impacts on amyloid-beta (Abeta) production, Abeta clearance, Abeta fibrillation, and tangle formation as well as on mitochondrial functions leading to neuronal toxicity and synaptic damage. This review summarizes the pathological cross talk between ApoE and Abeta peptide in Alzheimer's disease. Lastly, we examine emerging gene-based therapeutic approaches encompassing the use of ApoE and their potential opportunities to preventing or treating Alzheimer's disease.
Starting Page	35
Ending Page	48
Page Count	14
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.cnr.it/istituti/Allegato_20095.pdf?LO=01000000d9c8b7a6090000000c0000000e2400005e4c9b53000000000100000000000000000000000000000000000000000000000000000000000000000000000000000000000000&type=application/pdf
PubMed reference number	20182014v1
Alternate Webpage(s)	https://doi.org/10.3233/JAD-2010-100009
DOI	10.3233/jad-2010-100009
Journal	Journal of Alzheimer's disease : JAD
Volume Number	21
Issue Number	1
Language	English
Access Restriction	Open
Subject Keyword	Adverse reaction to drug Alleles Alzheimer's Disease Amino Acid Substitution Amino Acids Amyloid beta-Peptides Apolipoprotein E Apolipoprotein E2 Apolipoprotein E3 Apolipoprotein E4 Apolipoproteins Cell secretion Cholesterol Disclosure Globule Dosage Form Glucose LDLR protein, human Lipid Transport Lipoprotein Receptor Lipoproteins Nerve Degeneration Nervous system structure Neurodegenerative Disorders Neurofibrillary degeneration (morphologic abnormality) Neuronal Outgrowth Oxidative Stress Phospholipids Promotion (action) Protein Isoforms Senile Plaques Sulfoglycosphingolipids Therapeutic procedure Ventricular Fibrillation
Content Type	Text
Resource Type	Article