NDLI: Effect of metabolic control on interferon-gamma and interleukin-10 production by peripheral blood mononuclear cells from type 1 and type 2 diabetic patients.

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Effect of metabolic control on interferon-gamma and interleukin-10 production by peripheral blood mononuclear cells from type 1 and type 2 diabetic patients.

Content Provider	Semantic Scholar
Author	Foss-Freitas, Maria Cristina Foss, Norma Tiraboschi Donadi, E. A. Foss, Milton César
Copyright Year	2007
Abstract	The objective of the present study was to evaluate the production of cytokines, interferon-gamma (INF-gamma) and interleukin-10 (IL-10), in cultures of peripheral blood mononuclear cells (PBMC) from type 1 and type 2 diabetic patients and to correlate it with inadequate and adequate metabolic control. We studied 11 type 1 and 13 type 2 diabetic patients and 21 healthy individuals divided into two groups (N = 11 and 10) paired by sex and age with type 1 and type 2 diabetic patients. The PBMC cultures were stimulated with concanavalin-A to measure INF-gamma and IL-10 supernatant concentration by ELISA. For patients with inadequate metabolic control, the cultures were performed on the first day of hospitalization and again after intensive treatment to achieve adequate control. INF-gamma levels in the supernatants of type 1 diabetic patient cultures were higher compared to type 2 diabetic patients with adequate metabolic control (P < 0.001). Additionally, INF-gamma and IL-10 tended to increase the liberation of PBMC from type 1 and 2 diabetic patients with adequate metabolic control (P = 0.009 and 0.09, respectively). The increased levels of INF-gamma and IL-10 released from PBMC of type 1 and 2 diabetic patients with adequate metabolic control suggest that diabetic control improves the capacity of activation and maintenance of the immune response, reducing the susceptibility to infections.
Starting Page	498
Ending Page	505
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.scielo.br/pdf/bjmbr/nahead/6542.pdf
Alternate Webpage(s)	http://www.scielo.br/pdf/bjmbr/v40n5/6542.pdf
PubMed reference number	17464429v1
Volume Number	40
Issue Number	5
Journal	Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
Language	English
Access Restriction	Open
Subject Keyword	Brain Diseases, Metabolic Concanavalin A Diabetes Mellitus Hospitalization IL10 protein, human Infection Interferon Type II Interleukin Receptor Common gamma Subunit Patients Peripheral Neuropathy Peripheral blood mononuclear cell (cell) interleukin-10 production
Content Type	Text
Resource Type	Article

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