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Immunotherapy in Alzheimer’s Disease: Do We Have All the Pieces of the Puzzle?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sarazin, Marie Dorothée, Guillaume Souza, Leonardo Cruz De Aucouturier, Pierre |
| Copyright Year | 2013 |
| Abstract | Results of Phase III studies involving a large number of Alzheimer's disease (AD) patients treated by passive immunotherapy with humanized anti-amyloid β monoclonal antibodies have recently been released. These approaches failed to show a significant clinical benefit in patients with mild to moderate AD. The most considered explanation is that the patients have been treated too late. Whereas targeting patients at asymptomatic stages of the disease is a critical step in the goal of improving the efficacy of such antibody-based strategies, several other important factors should be considered in the development and clinical evaluation of anti-amyloid β immunotherapies, including the as yet poorly understood relationship of AD with the immune system and the importance of cerebral amyloid angiopathy. Better understanding the role of immune responses in AD and their impact on immunotherapy appears essential in the design of alternative or combinatorial immunotherapy approaches in AD, which may imply effectors other than antibodies and even additional antigenic targets. |
| Starting Page | 329 |
| Ending Page | 332 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.biopsych.2013.04.011 |
| PubMed reference number | 23683656 |
| Journal | Medline |
| Volume Number | 74 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0006322313003582 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0006322313003582?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.biopsych.2013.04.011 |
| Journal | Biological Psychiatry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
