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Management of hyperglycemia from epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) targeting T790M-mediated resistance.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Villadolid, Jeryl J. Ersek, Jennifer Lynne Fong, Mei Ka Sirianno, Lindsey Story, E. Shannon |
| Copyright Year | 2015 |
| Abstract | Epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) patients are associated with sensitivity to small molecule tyrosine kinase inhibitors (TKIs) such as erlotinib, gefitinib, and afatinib. Although studies show an increased progression free survival (PFS) with use of EGFR TKIs in the first-line setting, most patients will develop resistance to therapy after the first 8-16 months. T790M is an acquired resistance mutation reported in 60-70% of patients who initially responded to a prior EGFR TKI. Recently, EGFR TKIs targeting T790M have been developed to overcome resistance with positive results in PFS and objective response rate in patients who have had disease progression on at least one TKI. Two EGFR TKIs targeting T790M, AZD9291 and rociletinib, are new active treatment options for NSCLC but differ in adverse effect profiles. Dose-limiting hyperglycemia has been reported with rociletinib and has required dose reduction, an oral antihyperglycemic, or both, without discontinuation of therapy. This suggests that patients may be effectively treated chronically for hyperglycemia associated with EGFR TKIs targeting T790M, however, guidelines for treatment of hyperglycemia in this setting have not been published. We discuss mechanisms of hyperglycemia associated with TKIs and initial management of hyperglycemia, including benefits and limitations of oral antihyperglycemic options, adjustment of therapy based on grade of hyperglycemia, and recommendations for follow-up glucose monitoring. |
| Starting Page | 175 |
| Ending Page | 181 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://tlcr.amegroups.com/article/download/5430/5389 |
| PubMed reference number | 26629426v1 |
| Alternate Webpage(s) | https://doi.org/10.3978/j.issn.2218-6751.2015.10.01 |
| DOI | 10.3978/j.issn.2218-6751.2015.10.01 |
| Journal | Translational lung cancer research |
| Volume Number | 4 |
| Issue Number | 5 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | AZD9291 Afatinib Epidermal Growth Factor Receptor Glucose Growth Factor Receptors Hyperglycemia Hypoglycemic Agents Mutation Non-Small Cell Lung Carcinoma Patients Progression-Free Survival Progressive Disease Protein Tyrosine Kinase Scientific Publication Small Molecule Small cell carcinoma of lung Tyrosine Kinase Inhibitors [MoA] benefit cellular targeting erlotinib gefitinib rociletinib |
| Content Type | Text |
| Resource Type | Article |
