Effect of the Dexamethasone-Ondansetron Combination Versus Dexamethasone-Aprepitant Combination to Prevent Postoperative Nausea and Vomiting.

Content Provider	Semantic Scholar
Author	Bilgen, Sevgi Kizilcik, Nurcan Haliloğlu, Murat Yıldırım, Gazi Kaspar, Elif Çiğdem Köner, Özge
Copyright Year	2018
Abstract	Objective Postoperative nausea and vomiting (PONV) is a common problem associated with general anaesthesia. The incidence can be as high as 80% in high-risk patients. Our primary objective was to compare the efficacy of the combination of dexamethasone-ondansetron and dexamethasone-aprepitant in patients undergoing laparoscopic surgery. Methods Seventy 18 to 60 years old patients scheduled for laparoscopic surgery were included in the study. Sixty-seven patients completed the study. Patients in the dexamethasone-aprepitant group (group DA, n=35) received 40 mg of aprepitant orally 1-2 hours before the induction of anaesthesia and 2 mL saline intravenously (iv) within the last 30 minutes of surgery; patients in the dexamethasone-ondansetron group (group DO, n=35) received oral placebo identical to aprepitant 1-2 hours before the induction of anaesthesia and 4 mg ondansetron iv within the last 30 minutes of surgery. All patients received 8 mg dexamethasone iv after the induction of anaesthesia. The primary outcome was a complete response (no postoperative nausea, retching and vomiting and no need for rescue antiemetic); the secondary outcomes were the incidence of nausea, retching, vomiting, the need of rescue antiemetic and opioid consumption within 24 hours after surgery. Results A complete response was not significantly different between the groups (group DO: 67%, DA: 69%) at 24 hours (p=0.93). The incidence of PONV and postoperative opioid consumption was similar between the groups. Conclusion The study was designed to evaluate whether the combination of dexamethasone-aprepitant is better than the combination of dexamethasone-ondansetron regarding the complete response for PONV in patients undergoing laparoscopic surgery. The results however showed that dexamethasone-aprepitant has not improved the complete response for PONV compared to dexamethasone-ondansetron.
Starting Page	373
Ending Page	380
Page Count	8
File Format	PDF HTM / HTML
DOI	10.5152/TJAR.2018.53179
PubMed reference number	30263861
Journal	Medline
Volume Number	46
Issue Number	5
Alternate Webpage(s)	https://www.journalagent.com/tard/pdfs/TARD_46_5_373_380.pdf
Alternate Webpage(s)	https://doi.org/10.5152/TJAR.2018.53179
Journal	Turkish journal of anaesthesiology and reanimation
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article