NDLI: Coordinated transcriptional regulation of the unc-25 glutamic acid decarboxylase and the unc-47 GABA vesicular transporter by the Caenorhabditis elegans UNC-30 homeodomain protein.

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Coordinated transcriptional regulation of the unc-25 glutamic acid decarboxylase and the unc-47 GABA vesicular transporter by the Caenorhabditis elegans UNC-30 homeodomain protein.

Content Provider	Semantic Scholar
Author	Eastman, Cg Horvitz, H. Robert Jin, Yishi
Copyright Year	1999
Abstract	An important aspect of the specification of neuronal fate is the choice of neurotransmitter. In Caenorhabditis elegans the neurotransmitter GABA is synthesized by the UNC-25 glutamic acid decarboxylase (GAD) and packaged into synaptic vesicles by the UNC-47 transporter. Both unc-25 and unc-47 are expressed in 26 GABAergic neurons of five different types. Previously, we have identified that the unc-30 homeobox gene controls the fate of 19 type D GABAergic neurons. We report here that the UNC-30 homeodomain protein transcriptionally regulates the expression of unc-25 and unc-47 in the 19 type D neurons. UNC-30 bound to the unc-25 and unc-47 promoters sequence-specifically. Mutations in the UNC-30 binding sites of the unc-25 and unc-47 promoters abolished the expression of reporter genes in the D neurons. The ectopic expression of UNC-30 induced the ectopic expression of reporter genes driven by the wild-type unc-25 and unc-47 promoters. Our data establish a mechanism for cell type-specific transcriptional coregulation of genes required for the synthesis and packaging of the neurotransmitter GABA.
File Format	PDF HTM / HTML
DOI	10.1523/JNEUROSCI.19-15-06225.1999
Alternate Webpage(s)	http://www.jneurosci.org/content/19/15/6225.full.pdf
Alternate Webpage(s)	http://web.mit.edu/horvitz/www/assets/publications/eastman1999.pdf
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/19/15/6225.full.pdf
PubMed reference number	10414952
Alternate Webpage(s)	https://doi.org/10.1523/JNEUROSCI.19-15-06225.1999
Journal	Medline
Volume Number	19
Issue Number	15
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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