Galanin antagonizes acetylcholine on a memory task in basal forebrain-lesioned rats.

Content Provider	Semantic Scholar
Author	Mastropaolo, J. A. Nadi, Najib Ostrowski, Nancy L. Crawley, Jacqueline N.
Copyright Year	1988
Abstract	Galanin coexists with acetylcholine in medial septal neurons projecting to the ventral hippocampus, a projection thought to modulate memory functions. Neurochemical lesions of the nucleus basalis-medial septal area in rats impaired choice accuracy on a delayed alternation t-maze task. Acetylcholine (7.5 or 10 micrograms intraventricularly or 1 micrograms micro-injected into the ventral hippocampus) significantly improved performance in the lesioned rats. Atropine (5 mg/kg intraperitoneally or 10 micrograms intraventricularly), but not mecamylamine (3 mg/kg intraperitoneally or 20 micrograms intraventricularly), blocked this action of acetylcholine, suggesting involvement of a muscarinic receptor. Galanin (100-500 ng intraventricularly or 200 ng into the ventral hippocampus) attenuated the ability of acetylcholine to reverse the deficit in working memory in the lesioned rats. The antagonistic interaction between galanin and acetylcholine suggests that endogenous galanin may inhibit cholinergic function in memory processes, particularly in pathologies such as Alzheimer disease that involve degeneration of basal forebrain neurons.
Starting Page	83
Ending Page	94
Page Count	12
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.pnas.org/content/85/24/9841.full.pdf
PubMed reference number	2462255v1
Volume Number	85
Issue Number	24
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Subject Keyword	Alzheimer's Disease Atropine Basal Forebrain Basal Nucleus of Meynert Cell Nucleus Galanin Mecamylamine Memory Disorders Muscarinic Acetylcholine Receptor Prosencephalon Septum of telencephalon mg/kg
Content Type	Text
Resource Type	Article