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Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shen, Jiahong Dong, Zhen Ping Zhou, Nani Cheng, Bing-Zhuo Ou, Zhi-Min Luo, Xi-Ping |
| Copyright Year | 2018 |
| Abstract | We achieved the effective controllable regioselective acylation of the primary hydroxyl group of uridine derivatives catalyzed by Lipase TL IM from Thermomyces lanuginosus with excellent conversion and regioselectivity. Various reaction parameters were studied. These regioselective acylations performed in continuous flow microreactors are a proof-of-concept opening the use of enzymatic microreactors in uridine derivative biotransformations. |
| Starting Page | 12614 |
| Ending Page | 12618 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C8RA01030G |
| Volume Number | 8 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c8/ra/c8ra01030g/c8ra01030g1.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/C8RA01030G |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |