Development and in Vitro Characterization of Atorvastatin Calcium Poloxamer 407 Solid Dispersion Systems

Content Provider	Semantic Scholar
Author	Nasrin, Fatema
Copyright Year	2014
Abstract	In vitro Dissolution behaviour of a poorly water-soluble drug, atorvastatin calcium (ATC) from its solid dispersion (SD) systems with poloxamer 407 (P407) has been investigated to develop a novel formulation with enhanced dissolution rate. Solid dispersion of drug-carrier ratios (1:0.5, 1:1, 1:1.5 and 1:2) prepared by solvent evaporation method, were premeditated for drug loading, saturation solubility and dissolution behavior. Saturation solubility study and dissolution test were carried out in both phosphate buffer (pH 7.4) media and distilled water. Solid dispersions were found effective to enhance the solubility of ATC significantly in all the media. In the dissolution study, SD at the ratio of 1:1 (drug: carrier) was found to be most effective, showed fastest and higher drug release. The higher ratios of poloxamer 407 (1:1.5 and 1:2) in SD were found to sustain the release rate of drug which might be owing to its gelling tendency in higher proportion at elevated temperature. Fourier Transform Infrared Spectroscopy (FT-IR) of solid dispersions with pure drug revealed no drug-carrier interactions. Thermogram and short term stability studies ensured that the prepared SDs were stable. So, solid dispersion may be an effective technique to prepare immediate and sustain release
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Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article