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NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/β-catenin signaling pathway
| Content Provider | Semantic Scholar |
|---|---|
| Author | Li, Jingrong Fang, Ruihua Wang, Jianqin Deng, Liehua |
| Copyright Year | 2018 |
| Abstract | Malignant melanoma is an aggressive skin cancer with a high mortality rate. Nucleolar protein 14 (NOP14) has been implicated in cancer development. However, the role of NOP14 in malignant melanoma progression remains largely unclear. In this study, we observed that malignant melanoma tissue showed NOP14 down-regulation compared to melanocytic nevi tissues. Moreover, we observed that NOP14 expression was significantly associated with melanoma tumor thickness and lymph node metastasis. NOP14 overexpression in melanoma cells suppressed proliferation, caused G1 phase arrest, promoted apoptosis, and inhibited melanoma cell migration and invasion. Further investigations revealed that NOP14 overexpression reduced the expression levels of Wnt3a, β-catenin, and GSK-3β of the Wnt/β-catenin pathway. In summary, we demonstrated that NOP14 inhibited melanoma cell proliferation and metastasis by regulating the Wnt/β-catenin signaling pathway. |
| File Format | PDF HTM / HTML |
| DOI | 10.1590/1414-431X20187952 |
| PubMed reference number | 30484495 |
| Journal | Medline |
| Volume Number | 52 |
| Alternate Webpage(s) | http://www.scielo.br/pdf/bjmbr/v52n1/1414-431X-bjmbr-52-1-e7952.pdf |
| Alternate Webpage(s) | https://doi.org/10.1590/1414-431X20187952 |
| Journal | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
