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Effect of aluminum on regional brain antioxidant defense status in Wistar rats.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Julka, Deepinder Gill, Kiran Dip |
| Copyright Year | 1996 |
| Abstract | This investigation gives a detailed analysis of oxidative stress conditions generated following chronic aluminum exposure (10 mg Al/kg body weight per day) for a period of 4 weeks. We observed a significant enhancement in the levels of lipid peroxidation at the completion of aluminium treatment. The antioxidant enzymes, superoxide dismutase, catalase and glutathione peroxidase were seen to decrease following aluminum exposure. A significant decrease in the nonprotein sulfhydryl (NPSH) group status was also observed along with a decreased NPSH:disulfide ratio, thus further accentuating the oxidative insult to tissue. In vitro addition of desferrioxamine was shown to reverse aluminum induced lipid peroxidation, suggesting the probable therapeutic role of the drug against aluminum neurotoxicity. |
| Starting Page | 475 |
| Ending Page | 505 |
| Page Count | 31 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://page-one.live.cf.public.springer.com/pdf/preview/10.1007/BF02576841 |
| PubMed reference number | 8875705v1 |
| Volume Number | 196 |
| Issue Number | 3 |
| Journal | Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aluminum Antioxidants CATALASE Deferoxamine GLUTATHIONE PEROXIDASE Lipid Metabolism Disorders Lipid Peroxidation Neurotoxicity Syndromes Oxidative Stress Probability Sulfhydryl Compounds Inhibitors Superoxide Dismutase Superoxides |
| Content Type | Text |
| Resource Type | Article |
