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Flux control exerted by overt carnitine palmitoyltransferase over palmitoyl-CoA oxidation and ketogenesis is lower in suckling than in adult rats.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Krauss, S. Lascelles, Carol V. Zammit, Victor A. Quant, Patti A. |
| Copyright Year | 1996 |
| Abstract | We examined the potential of overt carnitine palmitoyltransferase (CPT I) to control the hepatic catabolism of palmitoyl-CoA in suckling and adult rats, using a conceptually simplified model of fatty acid oxidation and ketogenesis. By applying top-down control analysis, we quantified the control exerted by CPT I over total carbon flux from palmitoyl-CoA to ketone bodies and carbon dioxide. Our results show that in both suckling and adult rat, CPT I exerts very significant control over the pathways under investigation. However, under the sets of conditions we studied, less control is exerted by CPT I over total carbon flux in mitochondria isolated from suckling rats than in those isolated from adult rats. Furthermore the flux control coefficient of CPT I changes with malonyl-CoA concentration and ATP turnover rate. |
| Starting Page | 94 |
| Ending Page | 97 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.biochemj.org/content/ppbiochemj/319/2/427.full.pdf |
| PubMed reference number | 8912677v1 |
| Volume Number | 319 |
| Part | 2 |
| Journal | The Biochemical journal |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acetyl-CoA C-Acyltransferase Adenosine Triphosphate Carbon Cycle Carbon Dioxide Carnitine O-Palmitoyltransferase Fatty Acids Flux Human body Ketone Bodies Ketones Palmitoyl-CoA Hydrolase Summation (document) Taxus fatty acid oxidation funding grant physical hard work |
| Content Type | Text |
| Resource Type | Article |
