Bisphosphonates and breast cancer incidence and recurrence.

Content Provider	Semantic Scholar
Author	Chlebowski, Rowan Col, Nananda F.
Copyright Year	2011
Abstract	Bisphosphonates are commonly used in patients with breast cancer to reduce skeletal-related events in metastatic disease and to mitigate bone loss associated with adjuvant therapy. Preclinical studies have shown that bisphosphonates may directly inhibit breast cancer cell proliferation and metastasis. Clinical trials evaluating the oral bisphosphonate clodronate as a component of adjuvant therapy identified a potential reduction in cancer recurrence. Subsequently, trials of zoledronic acid have demonstrated prolonged disease-free survival in postmenopausal or otherwise estrogen-depleted women with early breast cancer. In the ABCSG-12 trial, the addition of twice-yearly zoledronic acid (4 mg IV) to adjuvant endocrine therapy improved disease-free survival in premenopausal women undergoing ovarian suppression. Similar results were observed in postmenopausal women receiving aromatase inhibitors in the ZO-FAST trial, and in women who were at least 5 years past menopause in the AZURE trial. Four recent observational studies (2 cohort studies and 2 case-control analyses) generally support an association between oral bisphosphonate use and lower breast cancer incidence. Ongoing breast cancer adjuvant clinical trials are further evaluating bisphosphonates and, by their influence on contralateral cancers, may provide more evidence regarding the potential of bisphosphonates for breast cancer prevention.
Starting Page	93
Ending Page	101
Page Count	9
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://content.iospress.com/download/breast-disease/bd000324?id=breast-disease/bd000324
PubMed reference number	22142660v1
Alternate Webpage(s)	https://doi.org/10.3233/BD-2010-0324
DOI	10.3233/bd-2010-0324
Journal	Breast disease
Volume Number	33
Issue Number	2
Language	English
Access Restriction	Open
Subject Keyword	Aromatase Inhibitors Bisphosphonate-associated osteonecrosis Breast Cancer Cell Cell Proliferation Clodronate Diphosphonates Estrogens Hormone Therapy Malignant Neoplasms Mammary Neoplasms Menopause Neoplasm Metastasis Osteopenia Paget's Disease, Mammary Patients Pharmaceutical Adjuvants adjuvant therapy breast cancer prevention ovarian ablation zoledronic acid
Content Type	Text
Resource Type	Article