NDLI: So how do you know you have a macromolecular complex?

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So how do you know you have a macromolecular complex?

Content Provider	Semantic Scholar
Author	Dafforn, Timothy R.
Copyright Year	2007
Abstract	Protein in crystal form is at an extremely high concentration and yet retains the complex secondary structure that defines an active protein. The protein crystal itself is made up of a repeating lattice of protein-protein and protein-solvent interactions. The problem that confronts any crystallographer is to identify those interactions that represent physiological interactions and those that do not. This review explores the tools that are available to provide such information using the original crystal liquor as a sample. The review is aimed at postgraduate and postdoctoral researchers who may well be coming up against this problem for the first time. Techniques are discussed that will provide information on the stoichiometry of complexes as well as low-resolution information on complex structure. Together, these data will help to identify the physiological complex.
Starting Page	17
Ending Page	25
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1107/S0907444906047044
PubMed reference number	17164522
Journal	Medline
Volume Number	63
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/91/ed/d-63-00017.PMC2483502.pdf
Alternate Webpage(s)	http://journals.iucr.org/d/issues/2007/01/00/ba5100/ba5100.pdf
Alternate Webpage(s)	http://msg.mbi.ufl.edu/journalclub-f07/8oct2007.pdf
Alternate Webpage(s)	https://doi.org/10.1107/S0907444906047044
Journal	Acta crystallographica. Section D, Biological crystallography
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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