NDLI: Letrozole versus combined metformin and clomiphene citrate for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial.

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Letrozole versus combined metformin and clomiphene citrate for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial.

Content Provider	Semantic Scholar
Author	Hashim, Hatem Abu Shokeir, Tarek A. Badawy, Ahmed
Copyright Year	2010
Abstract	OBJECTIVE To compare the effect of letrozole with combined metformin and clomiphene citrate (CC) for ovulation induction in CC-resistant women with polycystic ovary syndrome (PCOS). DESIGN A randomized controlled trial. SETTING University teaching hospital and a private practice setting. PATIENT(S) Two hundred fifty anovulatory women (582 cycles) with CC-resistant PCOS. INTERVENTION(S) Patients received 2.5 mg of letrozole daily (123 patients, 285 cycles) or combined metformin-CC (127 patients, 297 cycles) for three treatment cycles. MAIN OUTCOME MEASURE(S) Ovulation rate, number of follicles, serum E(2), serum P, endometrial thickness, pregnancy, and miscarriage rates. RESULT(S) Ovulation occurred in 185/285 cycles (64.9%) in the letrozole group versus 207/297 cycles (69.6%) in the combined metformin-CC group, without statistically significant difference. The total number of follicles was significantly more in the combined metformin-CC group (4.4+/-0.4 vs. 6.8+/-0.3). A nonsignificant increase in endometrial thickness on the day of hCG administration was observed in the letrozole group (9.5+/-0.2 mm vs. 9.1+/-0.1 mm). No statistically significant difference regarding the pregnancy rate (PR) was observed between both groups (14.7% vs. 14.4%). CONCLUSION(S) Letrozole and combined metformin-CC are equally effective for inducing ovulation and achieving pregnancy in patients with CC-resistant PCOS.
File Format	PDF HTM / HTML
DOI	10.1016/j.fertnstert.2009.07.985
PubMed reference number	19732888
Journal	Medline
Volume Number	94
Issue Number	4
Alternate Webpage(s)	http://www.royanaward.com/files13/Dr%20Abu%20Hashim%20FS%202010.pdf
Alternate Webpage(s)	https://doi.org/10.1016/j.fertnstert.2009.07.985
Journal	Fertility and sterility
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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