Loading...
Please wait, while we are loading the content...
Similar Documents
Phyllodes Tumor of the Breast : Prognostic Assessment Using Immunohistochemistry
| Content Provider | Semantic Scholar |
|---|---|
| Author | Esposito, Nicole Nicosia |
| Abstract | the tumor’s “leaflike” projections into cystic spaces, sarcomatous stroma, and “fleshy” gross appearance. This term has since been discouraged as > 70% of these lesions follow a benign course and only rarely exhibit cystic degeneration; “phyllodes tumor”, coined by the World Health Organization in 1981, is now the preferred term. Clinically, phyllodes tumors resemble fibroadenomas but tend to occur in older women. As described by Lifshitz et al. (2003), they appear mammographically as lobulated, round, or oval masses with wellcircumscribed borders and rarely contain calcifications. Histologically, phyllodes tumors are characterized by a doublelayered epithelial component arranged in cleft-like ducts surrounded by a variably cellular spindled-cell stroma. The stromal component is usually prominent and can show morphologic patterns that range from fibroadenoma-like to frankly sarcomatous. Though comprised of both epithelium and stroma, it has been established through clonal analysis that the stroma alone is the neoplastic compartment in these tumors. Standard therapy includes mastectomy or wide local excision, depending on the degree of malignity and tumor size. Axillary lymph node dissection is currently not routinely performed, as the rate of lymph node metastases is < 1%. Rather, like sarcomas in general, metastases are via the hematogenous route and are strictly composed of the sarcomatous element of the primary breast tumor. The most common metastatic sites are lung and bone. Overall recurrent and visceral metastatic rates range from 8% to 20 Phyllodes Tumor of the Breast: Prognostic Assessment Using Immunohistochemistry |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://page-one.live.cf.public.springer.com/pdf/preview/10.1007/978-1-4020-8369-3_20 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anatomic Node Anatomical compartments Bone Tissue Clone Duct (organ) structure Fibroadenoma of breast Lymphadenopathy Mammary Neoplasms Mastectomy Multi-compartment model Nephroblastoma Phyllodes Tumor Physiologic calcification Projections and Predictions Sarcoma Stroma Structure of parenchyma of lung lymph nodes |
| Content Type | Text |
| Resource Type | Article |
