NDLI: SNAP23 promotes the malignant process of ovarian cancer

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SNAP23 promotes the malignant process of ovarian cancer

Content Provider	Semantic Scholar
Author	Sun, Qi Huang, Xing Zhang, Quanli Qu, Junwei Shen, Yang Wang, Xin Sun, Haijun Wang, Jie Xu, Ling Chen, Xiaoxiang Ren, Binhui
Copyright Year	2016
Abstract	BACKGROUND Ovarian cancer (OC) was the primary malignant gynecological cancer and SNARE protein is closely related with tumor progression. Here, we identified SNAP23, a member of SNARE complex, as a potential oncogene in OC. METHODS We determined the expression of SNAP23 in OC tissues and explored the clinical significance through bioinformatics analysis. The effects of SNAP23 on OC cell proliferation, migration, invasion, cell cycle and apoptosis were then evaluated in vitro. RESULTS SNAP23 is hyper-expressed in OC tumor tissues compared to normal tissues, and increased expression of SNAP23 is associated with a poor progression free survival (HR = 1.24, 95% CI = 1.07-1.44, p = 0.0042). SNAP23 knock down increases cell apoptosis and inhibits cell proliferation, migration and invasion of OC cells. GO analysis reveals that most genes correlated highly with SNAP23 were enriched in metabolic process. CONCLUSIONS Our data suggest that SNAP23 may serve as an oncogene promoting tumorigenicity of OC cells by decreasing apoptotic process.
Starting Page	543
Ending Page	570
Page Count	28
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://ovarianresearch.biomedcentral.com/track/pdf/10.1186/s13048-016-0289-9
PubMed reference number	27855700
Volume Number	9
Journal	Journal of ovarian research
Language	English
Access Restriction	Open
Subject Keyword	Apoptosis Body tissue Cell Cycle Cell Proliferation Contraceptives, Oral Gynecology Hyperactive behavior Malignant neoplasm of ovary Metabolic Process, Cellular Metabolism Neoplasms Oncogenes Progression-Free Survival Promotion (action) SNAP23 gene Tumor Progression Tumorigenicity ovarian neoplasm
Content Type	Text
Resource Type	Article

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