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Fluorescent dissolved-core alginate microsphere glucose biosensors
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chaudhary, Ayesha Srivastava, Rohit |
| Copyright Year | 2009 |
| Abstract | The significance of diabetic control has resulted in worldwide efforts to develop implantable, noninvasive or minimally-invasive glucose sensors also known as “smart tattoos” (McShane, 2002, Chinnayelka et al., 2005, Brown et al., 2006, Chaudhary et al., 2008) intended for injection directly into the dermis, for continuous glucose monitoring. Such implants may be interrogated noninvasively using simple optical instrumentation (McShane et al., 2000) making their use all the more attractive. Several embodiments of potentially-implantable probes involving changes in resonance energy transfer (Chinnayelka et al., 2005, Chaudhary et al., 2008) that occur due to competitive binding of fluorescent ligand (FITC-dextran) and analyte (glucose) to occupy binding sites on a fluorescent receptor (Concanavalin A/ apo—glucose oxidase/ genetically engineered glucose-binding proteins (Tolosa et al., 1999, D'Auria et al., 2000) have been demonstrated. While the encapsulation of sensing reagents in the hollow nanoengineered capsules is elegant, and overcomes the major limitations of hydrogel-only entrapment (Russell et al., 1999, Rounds et al., 2007), the diffusion-limited post-fabrication loading of the sensing assay into the microcapsules is not efficient. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://impascience.eu/bioencapsulation/340_contribution_texts/2009-09-24_O06-3.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
