Cognitive reserve predicts future executive function decline in older adults with Alzheimer's disease pathology but not age-associated pathology

Content Provider	Semantic Scholar
Author	McKenzie, Cathryn Bucks, Romola S. Weinborn, Michael Bourgeat, Pierrick
Copyright Year	2020
Abstract	Cognitive reserve has been described as offering protection against Alzheimer's disease (AD) and other neurodegenerative conditions, but also against age-associated brain changes. Using data from the Alzheimer's Disease Neuroimaging Initiative, we defined cognitive reserve using the residual reserve index: episodic memory performance residualized for 3T MRI-derived brain volumes and demographics. We examined whether cognitive reserve predicted executive function (EF) decline equally across 2 groups of older adults-AD biomarker-positive (n = 468) and -negative (n = 402)-defined by the tau-to-amyloid ratio in cerebrospinal fluid. A significant interaction between the residual reserve index and biomarker group revealed that the effect of cognitive reserve on EF decline was dependent on pathology status. In the biomarker-positive group, higher cognitive reserve predicted EF decline over five years. However, cognitive reserve did not predict EF decline in the biomarker-negative group. These results suggest a certain level of AD pathology may be needed before cognitive reserve exerts its protective effects on future cognition; however, further research that tracks cognitive reserve longitudinally is needed.
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DOI	10.1016/j.neurobiolaging.2019.12.022
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0197458019304518
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0197458019304518?dgcid=api_sd_search-api-endpoint
PubMed reference number	31980279
Alternate Webpage(s)	https://doi.org/10.1016/j.neurobiolaging.2019.12.022
Journal	Medline
Journal	Neurobiology of Aging
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article